FDA-approved immunosuppressants targeting staphylococcal superantigens: mechanisms and insights
نویسندگان
چکیده
منابع مشابه
FDA-approved immunosuppressants targeting staphylococcal superantigens: mechanisms and insights
Immunostimulating staphylococcal enterotoxin B (SEB) and related superantigenic toxins cause diseases in human beings and laboratory animals by hyperactivating cells of the immune system. These protein toxins bind to the major histocompatibility complex class II (MHC II) molecules and specific Vβ regions of T-cell receptors (TCRs), resulting in the stimulation of both monocytes/macrophages and ...
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Staphylococcal enterotoxins are a family of structurally related proteins that are produced by Staphylococcus aureus. In addition to their role in the pathogenicity of food poisoning, these microbial superantigens have profound effects on the immune system, which makes them useful tools for understanding its mechanism of action. These molecules (24-30 kDa) are highly hydrophilic and exhibit low...
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Superantigens (SAgs) are a family of potent immunostimulatory exotoxins known to be produced by only a few bacterial pathogens, including Staphylococcus aureus. More than 20 distinct SAgs have been characterized from different S. aureus strains and at least 80% of clinical strains harbor at least one SAg gene, although most strains encode many. SAgs have been classically associated with food po...
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Staphylococcal enterotoxin B (SEB) of Staphylococcus aureus, and related superantigenic toxins produced by myriad microbes, are potent stimulators of the immune system causing a variety of human diseases from transient food poisoning to lethal toxic shock. These protein toxins bind directly to specific Vβ regions of T-cell receptors (TCR) and major histocompatibility complex (MHC) class II on a...
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ii To my parents for their infinite love, support, and understanding iii Do not go where the path may lead, go instead where there is no path and leave a trail Ralph Waldo Emerson iv ACKNOWLEDGMENTS First and foremost, I want to extend my deepest thanks to my advisor Dr. Patrick Schlievert for his exceptional mentoring and guidance. Pat is a true mentor in every sense of the word. Pat does not ...
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ژورنال
عنوان ژورنال: ImmunoTargets and Therapy
سال: 2017
ISSN: 2253-1556
DOI: 10.2147/itt.s125429